【摘要】 目的探讨GDM患者并发症的相关危险因素。方法 134例GDM患者分为无并发症组及并发症组。测定两组C-RP、FPG、FIns及血脂水平;记录母婴并发症发生情况;分析各危险因素与并发症的相关性。结果 GDM+并发症组C-RP、FPG、孕前BMI和孕晚期BMI均高于单纯GDM组[(5.46±4.20)vs(2.60±2.76)mg/L、(5.68±1.36)vs(5.25±0.77)mmol/L、(24.79±3.92)vs(23.03±2.51)kg/m2、(29.05±3.79)vs(27.25±2.58)kg/m2](P<0.05)。相关分析显示,C-RP与FPG呈正相关(P<0.05)。Logistic回归分析显示,孕晚期BMI、C-RP、TG和HDL-C是母体发生并发症的危险因素;C-RP是新生儿发生并发症的危险因素。结论 C-RP、血脂、孕晚期BMI与GDM母婴并发症发生密切相关;积极控制血糖、合理控制体重增加和血脂有助于减轻炎症反应,改善妊娠不良结局。更多还原

【Abstract】 Objective To explore the risk factors of pregnancy complications in patients with gestational diabetes mellitus(GDM). Methods 134 patients with GDM were divided into control group without complication(n=38)and complication group(n=96).Serum fasting levels of glucose(FPG),insulin,lipid and C-reactive protein(C-RP)were measured.Both maternal and fetal complications of pregnancy were recorded. Results The levels of C-RP,FPG,progestation BMI and lategestation BMI were significantly increased in complication group than in control group [(5.46±4.20)vs(2.60±2.76)mg/L,(5.68±1.36)vs(5.25±0.77)mmol/L,(24.79±3.92)vs(23.03±2.51)kg/m2,(29.05±3.79)vs(27.25±2.58)kg/m2 respectively,P<0.05].The C-RP level is significantly associated with FPG.Logistic analysis showed that maternal complications were significantly related to lategestation BMI,C-RP,TC and HDL-C.Infant complications were significantly related to C-RP. Conclusion C-RP,lipid and late gestation BMI play important roles in the development of maternal-neonatal complications during pregnancy.Keeping rational levels of glucose,lipid and weight gain are helpful for improving pregnancy outcomes.更多还原