【摘要】 目的探讨T2DM合并高尿酸血症(HUA)患者与FC-P和IR的相关性。方法纳入T2DM患者353例,按血清尿酸(SUA)水平分为T2DM合并HUA(T2DM+HUA)组57例和单纯糖尿病(T2DM)组296例。根据FC-P水平采用四分位数法分为C1(<1.5ng/ml)、C2(1.5~1.8ng/ml)、C3(1.8~2.7ng/ml)和C4(≥2.7ng/ml)亚组。结果两组BMI、TG、HDL-C、LDL-C、胰岛素抵抗指数(HOMA-IR)、ISI、FC-P、Scr、肾小球滤过率(eGFR)、动脉硬化指数(ASI)比较,差异均有统计学意义(P均<0.05)。相关分析结果显示,SUA与血脂、肾功能、HOMA-IR和FC-P有相关性(P均<0.05)。各亚组SUA水平和HUA发病率随FC-P水平逐渐升高(P均<0.05)。与C1~C3亚组相比,C4亚组发生T2DM合并HUA的风险增加(P=0.026),校正相关因素后,OR减少,差异无统计学意义(P=0.057)。结论 T2DM患者合并HUA与FC-P、IR及血脂异常相关,FC-P高可能是T2DM患者发生HUA的危险因素。更多还原

【Abstract】 Objective To investigate the relationship of hyperuricemia with fasting C peptide(FC-P)and insulin resistance(IR)in T2 DM patients. Methods The 353 T2 DM patients were divided into T2 DM with(T2DM+ HUA)and without(T2DM)high uric acid group.Meanwhile,All subjects were divided into four FC-P subgroups:C1(<1.5ng/ml),C2(1.5~1.8ng/ml),C3(1.8~2.7ng/ml)and C4subgroup(≥2.7ng/ml). Results There were statistically significant differences in BMI,TG,HDL-C,LDL-C,HOMA-IR,ISI,FC-P,Scr,eGFR,and ASI between two groups(P<0.05).Correlation analysis showed that the SUA was correlated with lipids,renal function,HOMA-IR and FC-P(P<0.05).The level of SUA and HUA incidence were increased along with increased FC-P level among subgroups(P<0.05).The risk of T2 DM combined to hyperuricemia was higher in C4 subgroup than in any other subgroups(P=0.026).After adjusting the related risk factors,the OR was reduced,and there was no statistically significant differences(P = 0.057). Conclusion Hyperuricemiais correlated with FC-P,IR and dyslipidemia in T2 DM patient.The high FC-P level may be the risk factors for hyperuricemia in T2 DM patients.更多还原