【摘要】 目的探讨内分泌腺特异性血管内皮生长因子(EG-VEGF)在子宫内膜异位症(内异症)组织及异位病灶旁组织的表达及意义。方法采用免疫组化法检测2013年8月至2014年8月在中国医科大学附属盛京医院住院的32例内异症患者在位内膜、异位内膜、异位病灶旁卵巢及32例正常子宫内膜(对照组1)、15例正常卵巢(对照组2)中EG-VEGF的表达。结果异位内膜EG-VEGF表达量及阳性表达率[1.99±0.26(84.3%)],均高于在位内膜[1.65±0.34(65.6%)],P<0.05及P<0.01;在位内膜EG-VEGF表达量及阳性表达率[1.65±0.34(65.6%)],均高于对照组内膜[0.85±0.29(21.9%)],P<0.05。异位内膜EG-VEGF表达量及阳性表达率[1.99±0.26(84.3%)],均高于异位病灶旁卵巢组织[1.45±0.28(56.2%)],P<0.05;异位病灶旁卵巢EG-VEGF表达量及阳性表达率[1.45±0.28(56.2%)]均高于对照组卵巢[0.89±0.31(40.0%)],P<0.01及P<0.05。组间比较,差异均有统计学意义。结论子宫内膜异位症患者在位内膜、异位内膜及异位病灶旁组织中EG-VEGF表达的异常升高与内异症的发生及发展相关。更多还原

【Abstract】 Objective To investigate the expression and significance of endocrine specific vascular endothelial growth factor(EG-VEGF) in endometriosis and its lateral tissue.Methods Detected the expression of EG-VEGF by immunohistochemistry in 32 cases of endometriosis, eutopic and ectopic endometrium, the lateral tissue of endometriosis, control group 1(32 case of normal endometrium) and control group 2(15 cases of normal ovaries).Results The expression and positive expression rate of EG-VEGF in ectopic endometrium were higher than eutopic endometrium[1.99±0.26(84.3%),1.65±0.34(65.6%),respectively](P<0.05 and P<0.01);the expression and positive expression rate of EG-VEGF in eutopic endometrium were higher than control group1[1.65±0.34(65.6%),0.85±0.29(21.9%),respectively](P<0.05);the expression and positive expression rates of EG-VEGF in ectopic endometrium was higher than ovarian of ectopic lesion side[1.99±0.26(84.3%),[1.45±0.28(56.2%),respectively](P<0.05);the expression and positive expression rates of EG-VEGF in ovarian of ectopic lesion side were higher than control ovarian[1.45±0.28(56.2%), 0.89±0.31(40.0%)respectively](P<0.01 and P<0.05); between the two groups, the differences were highly statistically significant.Conclusion The abnormally high level of EG-VEGF in endometriosis lesions, its side tissue and eutopic endometrium is associated with the occurrence and development of endometriosis.更多还原