【摘要】 骨肉瘤(osteosarcoma,OS)发病率在儿童和青少年恶性肿瘤中居首位,目前的临床治疗方式以外科手术联合药物化疗为主。虽然已经在很大程度上提高了骨肉瘤患者的生存率,但当肿瘤发生转移时,骨肉瘤患者的5年生存率不足20%。因此利用骨肉瘤动物模型对该疾病进行研究,对进一步探索其病因及研发新的治疗药物或方式显得尤为重要。本文就近年骨肉瘤模型的应用做一简要综述。更多还原

【Abstract】 Osteosarcoma( OS) is the most common primary malignant bone tumor in children and adolescents.Currently,the combination of surgical resection and chemotherapy is the main method of treatment for OS in the clinic. Although,the survival rate has been greatly improved in OS patients with localized disease,the 5-year survival rate has remained < 20%. It is very important to understand the cause of disease,to develop novel drugs or therapeutics,and to learn the disease through animal models. This review will introduce the progress of animal models of osteosarcoma over the last years.更多还原