【摘要】 目的采用不同免疫程序,评价成人接种重组乙型肝炎(乙肝)疫苗(汉逊酵母)[Recombinant Hepatitis B Vaccine(Hansenula polymorpha),Hep B]的免疫效果。方法选择柯桥区年龄在16~49岁的健康成人且无Hep B接种史和接种禁忌,实验室筛检乙肝病毒(Hepatitis B Virus,HBV)标志物乙肝病毒表面抗原(HBV Surface Antigen,Hbs Ag)、抗乙肝病毒表面抗原抗体(Antibody to Hbs Ag,Anti-HBs)、抗乙肝病毒核心抗原抗体(Antibody to HBV Core Antigen,Anti-HBc)均阴性。所有研究对象均进行问卷调查。3个乡镇分别选用"0-1-3月"、"0-1-6月"、"0-1-12月"免疫程序,接种完成1个月后检测Anti-HBs阳性率、抗体滴度水平进行评价。比较不同免疫程序免疫后的Anti-HBs阳性率、抗体滴度水平。采用多因素分析方法确定排除其他因素影响后,免疫程序对抗体应答的影响。结果 "0-1-3月"、"0-1-6月"、"0-1-12月"各组Anti-HBs阳转率分别为98.01%、98.43%、93.65%,差异有统计学意义(χ~2=7.70,P<0.05)。各组Anti-HBs几何平均浓度(Geometric Mean Concentration,GMC)分别为807.89 m IU/ml、930.68 m IU/ml、720.28 m IU/ml,差异无统计学意义(K=0.32,P=0.85)。多因素分析显示,在排除性别、年龄等影响因素后,抗体水平与免疫程序无关。结论成人Hep B"0-1-3月"、"0-1-6月"、"0-1-12月"免疫程序均可获得较好的抗体应答,"0-1-3月"和"0-1-6月"组阳转率略高于"0-1-12月"组,其长期效果需进一步随访。更多还原

【Abstract】 Objective To compare the immune response on different immunization schedules of 10μg hepatitis B vaccine( Hansenrla Polymorpha) in adults. Methods Adults aged 16 to 49 years,without hepatitis B vaccination history and contraindications to vaccination,were selected as subjects,and their hepatitis B virus( HBV) markers of HBV surface antigen( HBs Ag),antibody to HBs Ag( Anti-HBs) and antibody to HBV core antigen( Anti-HBc) were all negative through laboratory screening. Questionnaire investigation was made. Three townships in Keqiao were chosen for "0-1-3 months","0-1-6months"and"0-1-12 months"immunization schedules. Anti-HBs was detected 1month after vaccination,then the positive rates and the levels of anti-HBs among different groups of immunization schedules were compared. Multivariate analysis was used to find the impact of different immunization schedules on immune responses after adjusting the other influencing factors including age and gender. Results The anti-HBs positive rates of "0-1-3 months","0-1-6 months"and "0-1-12 months"groups were 98. 01%,98. 43%and 93. 65%,respectively. There was statistically significant differences in the positive rates among different immunization schedule groups( χ~2= 7. 70,P < 0. 05). The anti-HBs GMC of three groups were807. 89 m IU / ml、930. 68 m IU / ml and 720. 28 m IU / ml, respectively, with no statistically significant differences among the groups.Conclusions Good effect could be achieved by different immunization schedules among adults.The anti-HBs positive rates seems a little higher after vaccinating with "0-1-3 months " or ""0-1-6months"schedules than with "0-1-12 months"schedule. The long-term immune effect is necessary to follow up.更多还原