【摘要】 目的调查新疆维吾尔族、汉族非综合征型唇腭裂(NSCL/P)可疑危险因素,分析维、汉族危险因素异同点并提出有效预防措施。方法采用病例-对照研究方法,收集新疆维吾尔族、汉族NSCL/P病例、对照共290例,进行危险因素单因素、多因素logistic回归分析。结果维吾尔族NSCL/P病例-对照研究中,性别(P<0.05)、母亲平时健康情况(P<0.05)、孕期有无感冒(P<0.05)差异有统计学意义;汉族NSCL/P病例-对照研究中,父亲文化程度(P<0.05)、母亲孕早期工作强度(P<0.05)、父亲是否饮酒(P<0.05)差异有统计学意义。结论维吾尔族和汉族NSCL/P危险因素存在民族差异;性别为男、母亲孕期健康差、母亲孕期感冒是维吾尔族NSCL/P的可能危险因素;父亲文化程度低、母亲孕早期工作过度、父亲饮酒是汉族NSCL/P的可能危险因素。更多还原

【Abstract】 Objective To investigate risk factors of nonsyndromic cleft lip with or without cleft palate(NSCL/P)among Uygur and Han populations in Xinjiang Uygur Autonomous Region(Xinjiang) for making effective preventive measures. Methods A case-control study was carried out among 185 Uygur and Han cases and 105 age-,sex-,and ethnic-matched controls selected from 6 hospitals in Xinjiang;the data collected by a face-to-face interview were analyzed with univariate and multivariate logistic regression analysis. Results There were significant differences in gender,maternal health condition,and maternal history of getting cold during the pregnancy betw een Uygur NSCL/P cases and controls(all P < 0. 05);significant differences between Han NSCL /P cases and controls were also observed in education level and alcohol drinking history of the father,maternal working intensity during the early pregnancy(all P < 0. 05). Conclusion Ethnic differences exist in NSCL/P risk factors betw een Uygur and Han populations. Male gender,maternal illness conditions,maternal history of getting cold during pregnancy are risk factors of NSCL/P in Uygur population;education level and alcohol drinking history of the father,heavy working history during early pregnancy of the mother are risk factors of NSCL/P in Han population.更多还原