【摘要】 目的探讨重组人粒细胞集落刺激因子(rh G-CSF)对再生障碍性贫血治疗的可行性。方法选取2012年6月至2013年12月收治的再生障碍性贫血患者51例,随机分为观察组26例和对照组25例。对照组采用常规综合疗法治疗,观察组在常规综合疗法的基础上加用rh G-CSF皮下注射(5μg/kg,qd),疗程3个月。结果治疗后两组患者外周血白细胞计数(WBC)、血红蛋白(Hb)、血小板计数(PLT)均较治疗前升高,CD3+、CD4+、CD8+均较治疗前下降(P均<0.05);观察组各项指标改善均显著优于对照组(P均<0.05)。治疗后,两组患者粒系增生程度及巨核细胞个数均较治疗前明显增加(P均<0.05),且观察组各指标及骨髓增生活跃率均明显高于对照组(P均<0.05)。观察组感染发生率、感染次数及抗生素应用天数均较对照组明显减少(P均<0.05)。结论综合疗法联合rh G-CSF能迅速提高再生障碍性贫血治疗疗效,减少感染发生率,促进患者造血功能恢复。更多还原

【Abstract】 Objective To investigate the feasibility of recombinant human granulocyte colony stimulating factor(( rh GCSF)) for treating aplastic anemia. Methods Fifty-one patients with aplastic anemia admitted between June 2012 and December 2013 were selected,and the patients were randomly divided into observation group( n = 26) and control group( n =25). The conventional combining therapy was given in control group,and rh G-CSF( 5μg / kg,qd) was given by hypodermic injection on the basis of conventional combining therapy in observation group,and the treatment period of both groups were3 months. Results Compared with pre-treatment,peripheral blood leucocyte( WBC),hemoglobin( Hb) and platelet( PLT)significantly increased,and CD3 +,CD4 +,CD8 +significantly decreased after treatment in both two groups( all P < 0. 05),but the aforementioned indexes after treatment were significantly improved in observation group compared with control group( all P < 0. 05). Compared with pre-treatment,the hyperplasia degree of grain department and the number of megakaryocyte after treatment in both two groups significantly increased( all P < 0. 05),but the aforementioned indexes and the active rate of bone marrow hyperplasia after treatment in observation group were significantly improved compared with control group( all P < 0. 05). The incidence of infection,the number of infection and the course of antibiotics treatment in the observation group decreased significantly compared with control group( all P < 0. 05). Conclusions The therapy of rh G-CSF combined with conventional therapy can rapidly increase therapeutic effect,reduce incidence of infection and promote the recovery of hematopoietic function in the treatment of aptastic anemia patients.更多还原