【摘要】 目的通过超声监测胎儿颈项透明层厚度(NT),探讨NT增厚与胎儿染色体异常的关系。方法选取2010年1月~2013年12月到该院经腹超声检查胎儿NT增厚的孕妇165例,行早期绒毛或中期羊水穿刺进行胎儿染色体核型分析。结果 165例NT值增厚标本中,染色体培养成功率100%。染色体核型异常31例,异常比例是18.79%。异常核型中:21三体16例,18三体4例,13三体2例,45,X 3例,47,XXX 2例,47,XX,+mar 1例,其他3例。结论胎儿颈项透明层增厚对染色体异常早期筛查具有重要意义,是孕早中期产前超声筛查的主要指征之一。更多还原

【Abstract】 Objective:To explore the relationship between fetal thickened nuchal translucency monitored by ultrasound and chromosomal abnormalities.Methods:A total of 165 pregnant women receiving transabdominal ultrasonography for fetal thickened nuchal translucency in the hospital from January 2010 to December 2013 were selected,fetal karyotype analysis was performed based on chorionic villus test during the first trimester of pregnancy and amniocentesis during the second trimester of pregnancy.Results:Among 165 cases,the successful rate of chromosomal culture was 100%.The incidence rate of chromosomal abnormalities was 18.79%(31 cases),including 16 cases with trisomy 21,4 cases with trisomy 18,2 cases with trisomy 13,3 cases with 45,X,2 cases with 47,XXX,1 case with 47,XX,+mar,and 3 cases with the other abnormal karyotypes.Conclusion:Fetal thickened nuchal translucency is important for early screening of chromosomal abnormalities,which is one of the main indications for prenatal ultrasonic screening during the first and the second trimesters of pregnancy.更多还原