【摘要】 目的:探讨环境内分泌干扰物(EEDs)与儿童性早熟发病的相关性。方法:选择80例性早熟女童作为病例组,50例健康女童作为对照组,对比两组3种血清EEDs代表物——邻苯二甲酸二乙基己酯(DEHP)、辛基酚(OP)、双酚A(BPA)的浓度及子宫体积、卵巢体积,骨密度以及血清雌二醇水平。其中DEHP、OP和BPA采用高效液相色谱分析法测定,子宫体积、卵巢体积采用二维超声诊断仪测量,骨密度采用骨矿物质密度测定仪测定,血清雌二醇采用放射免疫分析法测定。分析EEDs代表物与儿童性早熟指标的相关性。结果:病例组DEHP、OP和BPA检测率和含量均高于对照组(P<0.05);病例组子宫体积、卵巢体积、骨密度和雌二醇水平均高于对照组(P<0.05),Pearson相关分析显示,DEHP与子宫体积、卵巢体积和骨密度呈显著正相关,OP与子宫体积呈显著正相关,BPA与子宫体积、卵巢体积呈显著正相关。结论:性早熟儿童EEDs暴露程度显著高于健康儿童,EEDs与性早熟密切相关,可能是性早熟发病的重要致病因素。更多还原

【Abstract】 Objective: To explore the correlation between environmental endocrine disrupter chemicals and childhood precocious puberty. Methods: Eighty girls with precocious puberty were selected as case group and 50 healthy girls were selected as control group. The concentrations of phthalic acid diethyl ester( DEHP),octyl phenol( OP) and bisphenol A( BPA) in serum,uterine volumes,ovarian volumes,bone mass index and serum estradiol levels in the two groups were compared. DEHP,OP and BPA concentrations were detected by high performance liquid chromatography; uterine volume and ovarian volume were detected by two- dimensional ultrasound diagnostic instrument; bone mineral density was determined by bone mineral density meter; serum estradiol level was detected by radioimmunoassay. The correlation between DEHP,OP,BPA and indexes of childhood precocious puberty was analyzed. Results: The detection rates and concentrations of DEHP,OP and BPA in case group were statistically significantly higher than those in control group( P < 0. 05); uterine volume,ovarian volume,bone mass index and estradiol level in case group were statistically significantly higher than those in control group( P <0. 05); Pearson correlation analysis showed that DEHP was positively correlated with uterine volume,ovarian volume,bone mass index,OP was positively correlated with uterine volume,BPA was positively correlated with uterine volume and ovarian volume. Conclusion: Compared with healthy children,more children with precocious puberty are exposed to environmental endocrine disrupter chemicals,environmental endocrine disrupter chemicals are closely correlated with precocious puberty,which may be an important pathogenic factor of precocious puberty.更多还原