【摘要】 目的探讨老年反流性食管炎患者生长激素释放多肽(Ghrelin)和瘦素(Leptin)血清水平及其在胃黏膜中表达的意义。方法选取老年反流性食管炎患者30例及正常对照组30例,采用ELISA法检测血清Ghrelin和Leptin水平,同时用免疫组化法检测胃黏膜中Ghrelin及Leptin的表达。结果老年反流性食管炎血清Ghrelin水平低于对照组,差异有统计学意义(P<0.05);血清Leptin水平高于对照组,差异有统计学意义(P<0.05);老年反流性食管炎胃黏膜Ghrelin表达阳性率(47%)显著低于正常对照组(76%),差异有统计学意义(P<0.05)。胃黏膜Leptin表达阳性率(83%)显著高于正常对照组(50%),差异有统计学意义(P<0.05)。老年反流性食管炎患者血清Leptin水平与Ghrelin水平呈负相关(P<0.05)。结论 Ghrelin、Leptin水平可能与老年反流性食管炎的发病有关,两者在反流性食管炎的发病中相互影响,生物学作用相反。更多还原

【Abstract】 Objective To investgate the serum level of ghrelin and leptin in the elderly patients with reflux esophag Itis and gastric mucosal.Methods A total of 30 elderly patients with reflux esophagitis and 30 of healthy control cases were selected,serum ghrelin and leptin were tested by ELISA and expression of ghrelin and leptin were decteted by immunohistochemistry.Results The serum level of ghrelin in the reflux esophagitis group was significantly lower than in the control group,the difference was significant(P<0.05).The serum level of leptin in reflux esophagitis group was sig nificantly higher than in the control group,the difference was significant(P<0.05).The expression positive rates of ghrelin in reflux esophagitis group(47%) were significant lower than in the control group(76%),the difference was significant(P<0.05).The expression positive rates of leptin in reflux esophagitis group(83%) were significant higher than the control group(50%),the difference was significant(P<0.05).There were negative correlation between the serum level of leptin and the serum level of ghrelin in patients with reflux esophagitis.Conclusion The level of ghrelin and leptin may be related to pathogenesis of reflux esophagitis.It is showed that the ghrelin and leptin may have opposite effect on each other in the pathogenesis of reflux esophagitis.更多还原