【摘要】 目的观察小剂量氯胺酮复合丙泊酚靶控输注(TCI)用于人工流产术的临床效果。方法选择门诊无痛人流患者100例,随机分为两组,每组50例。分别为芬太尼1μg/kg复合丙泊酚TCI组(F组)、氯胺酮0.2 mg/kg复合丙泊酚TCI组(K组)。比较两组患者开始静注药物时(T1)、意识消失时(T2)、清宫时(T3)、苏醒时(T4)的收缩压(SBP)、舒张压(DBP)、心率(HR)、脉搏氧饱和度(Sp O2)、起效时间、苏醒时间、准确定向时间、丙泊酚的总用量及术中知晓、苏醒期躁动、术后恶心、呕吐、眩晕等不良反应的发生情况;评价麻醉效果、丙泊酚注射痛发生率及程度。结果与F组比较:K组T2时点的SBP、DBP高于F组(P<0.05);T2~T4时点Sp O2高于F组(P<0.05)。K组丙泊酚注射痛发生率及程度均低于F组(P<0.05)。两组起效时间、苏醒时间、准确定向时间、丙泊酚的总用量、不良反应发生率、麻醉效果比较,差异无统计学意义(P>0.05)。结论小剂量氯胺酮复合丙泊酚靶控输注用于人工流产术具有良好的可行性及安全性。更多还原

【Abstract】 Objective To observe the clinical effects of low-dose ketamine combined with target-controlled infusion(TCI) of propofol used for artificial abortion. Methods One hundred outpatients underwent painless artificial abortion were randomly divided into two groups(n=50): ketamine combined with TCI of propofol,(group K) and fentanyl combined with TCI of propofol(group F). Systolic blood pressure(SBP); diastolic blood pressure(DBP); heart rate(HR);blood oxygen saturation(SpO2) were recorded at drug administration time(T1), loss of consciousness time(T2), curettage time(T3),and recovery time(T4). The onset time, awaking time, orientation time, the total dose of propofol were recorded. Also, the adverse reactions such intraoperative awareness,restlessness during waking-up period, nausea, vomiting,and dizziness of postoperative were recorded. Anesthesia effect and the degree and incidence of propofol injection pain were evaluated. Results Compared with group F, SBP、DBP at T2 and SpO2 during T2-T4 were higher in group K(P<0.05), while the degree and incidence of propofol injection pain were lower in group K(P<0.05). There was no significant difference in onset time, awaking time, orientation time, the total dose of propo fol and the incidence of adverse reactions between the two groups(P >0.05). Conclusion low-dose ketamine combined with target-control infusion of propofol for artificial abortion has better feasibility and security.更多还原