【摘要】 目的探讨前列腺偶发癌的临床病理特征。方法对16例前列腺偶发癌临床病理特征进行回顾性研究,并进行文献复习。结果前列腺偶发癌患者平均发病年龄为71.6岁,其组织形态多以单个分离的小腺泡为主,比正常略小而更密集,癌细胞可见核仁;P504S在癌组织中呈阳性表达,34βE12、P63、CK5/6在癌组织周边呈阴性表达,Ki-67在癌组织中平均阳性率为15%,与对照的前列腺增生组织比较均有显著差异(P<0.05)。结论前列腺偶发癌临床及病理形态无特异性,对前列腺标本全部取材,结合HE形态及P504S、34βE12、P63、CK5/6、Ki-67免疫组化联合检测,能提高前列腺偶发癌的检出率。更多还原

【Abstract】 Objective To evaluate the clinicopathological characteristics of incidental carcinoma of the prostate gland(ICPG). Methods Clinicopathological characteristics of the 16 cases ICPG were analyzed retrospectively,and related references were reviewed. Results The average age of the 16 cases was 71.6 years. The structure of the ICPG were based on separated acini,smaller and more intensive than normal prostate glands,visible nucleoli. The positive expression rates of P504 S and Ki-67(15%) in ICPG were significantly higher than in benign prostatic hyperplasia(P<0.05).The positive expression rates of 34βE12,P63 and CK5/6 in ICPG were significantly lower than in benign prostatic hyperplasia(P<0.05). Conclusion It is not special in the clinical and pathological structure of ICPG. It can enhance the detection rate of ICPG from making all of the prostate sample and combining HE, immunohistochemical staining of P504 S, 34βE12, P63, CK5/6, Ki-67.更多还原