【摘要】 目的探讨鼻腔及鼻窦部内翻性乳头状肿瘤(IPT)的临床病理特征。方法对89例鼻腔及鼻窦部IPT进行回顾性临床病理分析。结果 89例中男性59例,女性30例,年龄24~85岁,平均55岁。临床常见症状为鼻塞、流涕、头痛、鼻出血和嗅觉减退等。病理诊断为内翻性乳头状瘤52例(58.4%),伴低级别上皮内瘤变22例(24.7%),伴高级别上皮内瘤变13例(14.6%),2例为移行细胞癌(2.2%)。随访60例,12例术后复发(13.5%),其中2例多次复发,2例出现肝、脑转移。结论鼻腔及鼻窦部IPT好发于中年男性,临床症状缺乏特异性,病理形态呈内翻性乳头状生长,39.3%肿瘤可以发生上皮内瘤变,13.5%患者术后出现复发,少数形成移行细胞癌并发生肝和脑转移。更多还原

【Abstract】 To investigate the clinicopathologic changes of transitional cell tumors of the sinuses.Methods 89 cases of inverted papillary tumors of nasal cavity and paranasal sinuses were studied by the histopathological examination and immuniohistochemical staining,retrospectively.Results 59 males and 30 females patients aged 24-85 years( mean55 years old).Clinically,nasal congestion( 78 cases),runny nose( 53 cases),headache( 32 cases) epistaxis( 27cases) and olfactory dysfunction presented as the main symptom.Inverted papilloma pathological diagnosis in 52 cases was made,accounting for 58.4%,low-grade intraepithelial neoplasia in 22 cases,accounting for 24.7%,13 cases of highgrade intraepithelial neoplasia( 14.6%),two cases of transitional cell carcinoma,accounted for 2.2%.Follow-up of 60 cases,showed 12 cases of recurrence,accounting for 13.5%,of which 2 cases had multiple recurrences,and 2 patients had metastases.Conclusion The sinus transitional cell tumors typically occur in middle-aged men,lack of specific clinical symptoms.The pathological most inverted papilloma growth was 39.3% of the tumor can occur intraepithelial neoplasia,13.5% of patients relapse after a ew transitional form cell carcinoma f and metastasis.更多还原