【摘要】 目的对甘草Glycyrrhiza uralensis根及根茎的化学成分进行研究。方法采用硅胶柱、ODS柱色谱、制备液相色谱等分离技术进行分离纯化,利用UV、MS、1D-NMR、2D-NMR等波谱数据鉴定化合物结构。结果从甘草正丁醇部分分离得到14个化合物,分别鉴定为macedonoside E(1)、22β-乙酰基乌拉尔甘草皂苷C(2)、甘草酸(3)、乌拉尔甘草皂苷F(4)、甘草皂苷G2(5)、22β-乙酰基甘草醛(6)、甘草酸甲酯(7)、甘草素(8)、柚皮素(9)、异甘草素(10)、芒柄花苷(11)、甘草苷(12)、异佛来心苷(13)、芹糖甘草苷(14)。结论化合物1和2为新化合物。更多还原

【Abstract】 Objective To study the chemical constituents from the roots and rhizomes of Glycyrrhiza uralensis. Methods The roots and rhizome of G. uralensis were extracted with 95% Et OH. Then the extract was partitioned with petroleum ether, ethyl acetate, and n-butanol successively. The n-butanol fraction was isolated by silica gel and ODS column chromatography and preparative HPLC. The structures of compounds were identified by spectroscopic methods(UV, MS, 1D-NMR, and 2D-NMR). Results Fourteen compounds were obtained from the n-butanol fraction. They were macedonoside E(1), 22β-acetyl-uralsaponin C(2), glycyrrhizic acid(3), uralsaponin F(4), licorice-saponin G2(5), 22β-acetoxyl-glycyrrhaldehyde(6), 3β-O-[β-D-(6-methyl)-glucuronopyranosyl-(1 →2)-β-D-glucuronopyranosyl]-glycyrrhizic acid(7), liquiritigenin(8), naringenin(9), isoliquiritigenin(10), ononin(11), liquiritin(12), isoviolanthin(13), and liquiritin apioside(14). Conclusion Macedonoside E(1) and 22β-acetyl-uralsaponin C(2) are new compounds.更多还原