AIM: To study the effect of remifentanil on monophasic action potential and transmural dispersion of repolarization( TDR) in the 3-layer myocardium of isolated rabbit hearts. METHODS: Adult rabbits( n = 18,2. 0 ~2. 5 kg) were used to isolate the hearts for preparing Langendorff perfusion model. The hearts were randomly divided into 3groups after perfusion with K-H solution for 15 min: the perfusion in control group( C group) continued for 60 min; the hearts in remifentanil group( R group) were perfused with...
【基金】
贵州省科技厅联合基金资助项目(黔科合LG字[2011]015号)
【更新日期】
2015-02-23
【分类号】
R614
【正文快照】
瑞芬太尼是超短效的μ受体激动剂,可引起心率(heart rate,HR)减慢,甚至心律失常。心室肌具有电生理特性不同的3层(内膜层、中层、外膜层)心肌细胞,中层心肌细胞(M细胞)复极速度最慢,外膜层心肌细胞复极速度最快,可用跨室壁复极离散度(transmural dispersion of repolarization,