【摘要】 目的观察左西替利嗪口服液治疗儿童慢性荨麻疹的疗效和安全性。方法将入选的156例慢性荨麻疹患儿随机分为两组,治疗组(78例)予左西替利嗪口服液治疗,对照组(78例)予西替利嗪口服液治疗,均1次/d,连用28d,分别于治疗第14和28天时观察临床疗效和不良反应。结果治疗第14和28天时,治疗组有效率分别为84.62%和87.18%,对照组分别为79.49%和83.33%,差异无统计学意义(P>0.05)。治疗组不良反应发生率(6.41%)明显低于对照组(16.67%),主要有口干、嗜睡,且差异有统计学意义(P<0.05)。结论左西替利嗪口服液和西替利嗪口服液治疗儿童慢性荨麻疹的疗效相当,但左西替利嗪安全性高于后者。更多还原

【Abstract】 Objective To observe the efficacy and safety of levocetirizine oral solution in pediatric patients with chronic urticaria. Methods A totle of 156 children with chronic urticaria were enrolled and divided into 2 groups randomly. The treatment group( 78 cases) were treated with levocetirizine oral solution one-time-a-day for 28 days,and the control group( 78 cases) were treated with cetirizine oral solution with the same durg use frequence. Efficacy and adverse reactions were observed at day 14 and day 28. Results The effective rates in the treatment group were 84. 62% and 87. 18% at day 14 and day 28,and that in the control group were79. 49% and 83. 33% respectively. There was no significant difference between the two groups( P > 0. 05).However the adverse reaction in treatment group( 6. 41%) were lower than that in control group( 16. 67%),which include mouth dryness,dizziness. There were significant differences between the two groups( P < 0. 05). Conclusion There is no difference between levocetirizine and cetirizine in the treatment of chronic urticaria in children. Levocetirizine produced fewer side effects than cetirizine.更多还原