【摘要】 目的探讨重症药疹的临床特点及防治措施。方法对本科2002年8月-2013年11月诊治的重症药疹患者的临床资料进行回顾性分析。结果排名前三位的致敏药物分别为抗生素、抗癫痫药和解热镇痛药,最常见用药原因为感染。中成药引起的药疹内脏损害相对较轻。85例患者中,治愈61例,好转23例,1例死于肺部感染及呼吸衰竭。结论重症药疹是皮肤科危重病种,早期予以糖皮质激素联合免疫球蛋白效果较好,同时应加强对症及支持治疗。更多还原

【Abstract】 Objective To investigate the clinical features and prevention measures of severe drug eruptions. Methods Clinical data of patients suffered from severe drug eruptions from August 2002 to November 2013 in our department were analyzed retrospectively. Results The top three sensitization drugs were antibiotics,antiepileptic drugs and non-steroidal anti-inflammatory drugs. Infection was the most common reason for drug intake. Allergy-induced by traditional Chinese patent drug had less damage to internal organs. Sixty-one of 85 cases were cured,23 cases improved,only 1 case died of pulmonary infection and respiratory failure. Conclusion Severe drug eruptions are life-threatening cutaneous reactions. Combined usage of hormone and immunoglobulin in early stage could achieve satisfactory treatment response. Meanwhile symptomatic and supportive treatment should be strengthened.更多还原