【摘要】 目的探讨性激素17β-羟甾类固醇脱氢酶1[hydroxysteroid(17-beta)dehydrogenase1,HSD17B1]和性激素结合球蛋白(sex hormone-binding globulin,SHBG)单核苷酸多态性与四川地区汉族人群系统性红斑狼疮(systemic lupus erythematosus,SLE)之间的关系。方法以98例SLE患者和346例健康对照者为研究对象,采用聚合酶链反应-限制性片段长度多态(polymerase chain reaction-restriction fragment length polymorphisms,PCR-RFLP)技术对HSD17B1 rs676387和SHBG rs6259单核苷酸多态性位点进行基因分型。结果 SLE患者SHBG rs6259 A等位基因和AG基因型频率分布与正常对照组差异存在统计学意义(P<0.05),HSD17B1 rs676387等位基因和基因型频率分布与正常对照组之间差异无统计学意义(P>0.05)。结论 SHBG rs6259 A增加了四川汉族人群SLE发病易感性,提示SHBG rs6259 A可能参与了SLE的发病过程。更多还原

【Abstract】 Objective To investigate the association between the sex hormone hydroxysteroid( 17-beta) dehydrogenase1( HSD17B1) and sex hormone binding globulin( SHBG) gene single nucleotide polymorphisms with systemic lupus erythematosus( systemic lupus erythematosus,SLE) patients in Sichuan Han population.Methods Ninty-eight cases of SLE patients and 346 healthy control subjects were enrolled in present study.Polymerase chain reaction-restriction fragment length polymorphism( PCR-RFLP) methods were chosen to genotype the HSD17B1 rs676387 and SHBG rs6259 single nucleotide polymorphisms. Results There were statistically significant difference in distribution of SHBG rs6259 genotypes and alleles between SLE patients and normal control groups( P < 0. 05),while no difference was found in HSD17B1 rs676387 genotypes and alleles distribution( P > 0. 05). Conclusion SHBG rs6259 A increased the susceptibility of SLE in the Sichuan Han population,indicate that polymorphisms in SHBG rs6259 A may play a role in SLE development.更多还原