【摘要】 目的探讨核桃补充饮食对发育期小鼠认知功能的影响。方法初断乳昆明小鼠60只,体质量11~14g,分为:对照(常规饲料)、3%核桃和6%核桃(在常规饲料里核桃的配比分别为3%、6%)三组,分别采用旷场箱、避暗箱及八臂迷宫检测小鼠的自发活动、被动逃避能力及空间学习记忆能力,对比研究核桃对小鼠认知功能的改善作用。结果核桃干预对小鼠的摄食行为和体质量无影响。与对照组比,3%、6%核桃干预后小鼠的自主活动能力提高(P<0.05);3%核桃组探索活性增强(P<0.05),6%核桃组探索活性亦有增强趋势。八臂迷宫测试中,三组的总探索时间、参考记忆错误次数和工作记忆错误次数随天数增加均呈下降趋势。两个核桃干预组的参考记忆、工作记忆错误次数明显少于对照组(P<0.05),探索时间明显缩短(P<0.05)。结论核桃干预6w后,可使小鼠的自发活动能力增强、空间学习记忆能力显著提高,提示核桃能够明显改善发育期小鼠的认知功能。更多还原

【Abstract】 Objective To evaluate the effects of walnuts on cognitive performance in development stage of mice. Method 60 KM young mice, weighted 11-14 g, were divided into three groups: controls(fed with ordinary food) and two walnut groups(fed with walnuts, 3% and 6% of food intake) for 6 weeks. The effects of walnuts were monitored on food intake and body weight. Cognitive functions were determined by using the open field(OF), step-through passive avoidance and 8-arms radial maze tests. Results There were no significant difference in food intake and body weight between the controls and two walnut groups. In the open field, mice fed with walnuts(3% and 6% walnut groups) exhibited enhanced exploratory behavior and movement capability(P<0.05). The walnut diet improved working and reference memory compared to the controls in 8-arms radial maze test(P<0.05). The exploration time of both walnut-treated groups in the test was equivalent, but was significantly shorter than the controls. Conclusion These findings show that dietary walnut supplementation can improve locomotor activity, learning and memory in young mice.更多还原