【摘要】 目的:了解皖南医学院附属马鞍山市人民医院(以下简称"我院")2014年药品不良反应(adverse drug reaction,ADR)发生的特点及变化规律,促进临床合理用药。方法:对我院2014年收集上报的1 112例ADR报告进行统计分析。结果:1 112例ADR报告中,男性与女性的比例为1.24∶1;60岁以上者占51.35%;新的、严重的ADR占27.79%;给药途径以静脉滴注为主,占72.21%;抗菌药物引发的ADR例数占25.63%,抗肿瘤药引发的ADR例数占13.94%;ADR累及器官或系统以皮肤及附件损害和消化系统损害为主,分别占35.25%和34.17%。结论:临床应重视抗菌药物和抗肿瘤药的合理使用,加强ADR监测,以减少或避免ADR的发生。更多还原

【Abstract】 OBJECTIVE:To probe into the characteristics and changes of regularity of adverse drug reactions( ADR) reports reported by Ma‘anshan People’s Hospital Affiliated to Wannan Medical College( hereinafter referred to as "our hospital"),and to promote rational clinical use of drugs.METHODS:1 112 cases of ADR reports in our hospital in 2014 were collected and analyzed statistically.RESULTS:Of the 1 112 cases,the ratio of male to female was 1.24∶ 1;51.35% of ADR patients were over the age of 60 years old.27.79% of the cases were new and severe ADR and 72.11% were induced by intravenous administration.25.63% of the cases were caused by antibiotics,while13.94% were caused by antineoplastic drugs.ADR-involved organs or systems mainly focus on skin and its appendages damage and digestive system damage,respectively accounting for 35.25% and 34.17%.CONCLUSIONS:High attention should be payed to the rational use of antibiotics and antineoplastic drugs.The monitoring of ADR should be strengthened to reduce or avoid the incidence of ADR.更多还原