【摘要】 目的:探讨加替沙星与盐酸氨溴索联合治疗老年急性肺炎的临床疗效。方法:选择威海市立医院2013年7月—2014年12月收治的老年急性肺炎患者110例,以随机数字表法分为观察组和对照组,每组各55例。对照组患者给予左氧氟沙星与盐酸氨溴索联合治疗,观察组患者给予加替沙星与盐酸氨溴索联合治疗。对比观察2组患者的临床疗效、住院时间、细菌清除率及不良反应发生率等。结果:观察组患者的总有效率为96.36%(53/55)、细菌清除率为81.82%(45/55),均明显高于对照组的83.64%(46/55)、58.18%(32/55),差异均有统计学意义(P<0.05);观察组患者住院时间为(16.72±3.16)d,明显短于对照组的(20.48±4.27)d,差异有统计学意义(P<0.05);观察组患者再感染率为1.82%(1/55),明显低于对照组的12.73%(7/55),差异有统计学意义(P<0.05);观察组患者不良反应发生率为5.45%(3/55),与对照组的7.27%(4/55)比较,差异无统计学意义(P>0.05)。结论:加替沙星与盐酸氨溴索联合治疗老年急性肺炎,能有效清除患者体内的细菌,临床疗效较理想,不良反应较少,再感染率较低,值得临床推广。更多还原

【Abstract】 OBJECTIVE: To probe into the clinical efficacy of gatifloxacin combined with ambroxol hydrochloride in treatment of acute pneumonia in elderly patients. METHODS: 110 elderly patients with acute pneumonia from Jul.2013 to Dec. 2014 in Weihai Municipal Hospital were divided into observation group and control group via the random number table,with 55 cases in each group. The control group was given the treatment of levofloxacin combined with ambroxol hydrochloride,the observation group received gatifloxacin combined with ambroxol hydrochloride. The clinical efficacy,length of stay,bacteria clearance rate and the incidence of adverse reactions of the two groups were observed and compared. RESULTS: The total effective rate and bacterial clearance rate of the observation group was respectively 96. 36%( 53 /55) and 81. 82%( 45 /55),which were significantly higher than that of the control group[83. 64%( 46 /55) and 58. 18%( 32 /55) ],respectively; the difference was statistically significant( P < 0. 05). The length of stay of the observation group were( 16. 72 ± 3. 16) d,which were significantly shorter than that of the control group( 20. 48 ± 4. 27) d,the difference was statistically significant( P < 0. 05). The reinfection rate of the observation group was 1. 82%( 1 /55),which was significantly lower than that of the control group 12. 73%( 7 /55),the difference was statistically significant( P < 0. 05). The incidence of adverse reactions of the observation group was 5. 45%( 3 /55),compared with the control group of 7. 27%( 4 /55),there was no significant difference( P > 0. 05).CONCLUSIONS: Gatifloxacin combined with ambroxol hydrochloride in treatment of acute pneumonia in elderly patients can effectively remove the bacteria from the patients,the clinical efficacy is ideal,with fewer adverse reactions and lower infection rate. It is worthy of clinical promotion.更多还原