【摘要】 目的:探讨某院药品不良反应(adverse drug reaction,ADR)发生的特点及规律,为临床合理用药提供参考。方法:对某院2014年上报的665例ADR报告进行统计分析。结果:老年人、儿童患者ADR发生率高;665例ADR共涉及药物20类194种,其中抗感染药35种,共引发ADR 185例(占27.82%);引发ADR的给药途径以静脉给药为主,共550例;ADR累及器官和(或)系统方面,皮肤及其附件、消化系统、用药局部损害等发生率高。结论:ADR的影响因素有很多,应从医护人员、患者、政府等层面增强ADR上报意识、加强ADR监测与评价,确保用药安全。更多还原

【Abstract】 OBJECTIVE: To investigate the characteristics and regularity of the adverse drug reactions( ADRs) in a hospital for clinical reference of rational use of drugss. METHODS: A total of 665 ADR cases collected in a hospital during 2014 were statistically analyzed. RESULTS: The ADR occurred mostly in elderly patients and children. Of the665 cases,20 categories of drugs( 194 drugs) were involved; 185 cases( 27. 82%) were induced by 35 antiinfective drugs; the ADR was mostly induced by intravenously administered drugs( 550 cases) and manifested mainly as lesions of skin and its appendents,damage of digestive system and local lesion. CONCLUSIONS: ADR is associated with multiple factors,and it is important to enhance the awareness of ADR reporting among medical personnel,patients and government and strengthen ADR monitoring and evaluation so as to ensure medication safety.更多还原