【摘要】 目的:探讨乌司他丁干预对急性脑梗死患者血清D-二聚体、脑钠肽(brain natriuretic peptide,BNP)水平及认知功能的影响。方法:选取2012年1月—2013年1月急性脑梗死患者98例作为观察组,另选取30例健康自愿者作为对照组。观察组患者在基础治疗的基础上给予乌司他丁10万U静脉滴注,每8 h给药1次,连续治疗7 d。检测对照组人群和观察组患者治疗前和治疗1、3、5、7 d时血清D-二聚体、BNP水平,并采用蒙特利尔认知评估量表对2组人群进行认知功能评价。结果:治疗前,观察组患者血清D-二聚体、BNP水平均明显高于对照组(P<0.01)。观察组患者治疗3、5、7 d时血清D-二聚体、BNP水平均明显低于治疗前(P<0.05),并于治疗1 d时达到最高值[分别为(3.27±0.46)mg/L、(161.78±45.98)ng/ml],治疗7 d时达到最低值[分别为(1.67±0.76)mg/L、(109.67±31.78)ng/ml];观察组患者认知功能障碍发生率为28%(28.57%,28/98)。结论:乌司他丁干预可有效降低急性脑梗死患者血清D-二聚体、BNP水平,并可预防认知功能障碍的发生,是急性脑梗死的有效辅助治疗方法,值得临床推广。更多还原

【Abstract】 OBJECTIVE: To evaluate the effects of Ulinastatin intervention on serum levels of D-Dimers and brain natriuretic peptide( BNP) and cognition in patients with acute cerebral infarction. METHODS: Between January 2012 and January 2013,98 patients with acute cerebral infarction were assigned to observation group and another 30 healthy volunteers to control group. The patients in the observation group were given add-on ulinastatin( 10 0000 units) by intravenous drip infusion every 8 hours for 7 consecutive days. The two groups were measured at 0,1,3,5,7 days of treatment with regard to serum levels of D-dimmer and BNP,and the Montreal Cognitive Assessment Scale was employed for assessment of cognitive function of the two groups. RESULTS: Before treatment,serum levels of Ddimmer and BNP in the observation group were significantly higher than in the control group( P < 0. 01). At 3,5,and 7 days,serum levels of D-dimmer and BNP in the observation group were significantly lower than before treatment( P < 0. 05),which peaked to maximum at 1 day of treatment [( 3. 27 ± 0. 46) mg /L and( 161. 78 ± 4. 598) ng /ml,respectively] and decreased to minimum values at 7 days [( 1. 67 ± 0. 76) mg / L and( 10. 967 ± 31. 78) ng / ml,respectively]. 28%( 28. 57%,28 /98) of the patients in the observation group presented with cognitive impairment.CONCLUSIONS: Ulinastatin intervention can effectively reduce serum levels of D-dimmer and BNP and prevent the cognitive dysfunction in patients with acute cerebral infarction,which thus is an effective auxiliary therapy for acute cerebral infarction and worthy of clinical promotion.更多还原