【摘要】 目的:探讨阿托伐他汀钙强化降脂治疗对冠心病心绞痛患者病情及血清学指标的影响。方法:通过抽查电子病历,将2013年4月—2014年7月安徽省六安市中医院收治的150例服用阿托伐他汀钙的冠心病心绞痛患者纳入研究,患者均接受常规舒张冠脉、心肌营养、抗凝等治疗,以随机数字表法筛选接受阿托伐他汀钙强化降脂治疗和接受阿托伐他汀钙常规降脂治疗的患者各75例,分别为观察组和对照组,比较2组患者的心功能情况及血清炎症因子含量。结果:观察组患者的三酰甘油和胆固醇含量明显低于对照组,2组差异有统计学意义(P<0.05),而2组患者心、肝、肾功能指标的差异无统计学意义(P>0.05);观察组患者左心室射血分数、每搏输出量、左心室内径缩短率、室壁增厚率、室间隔运动幅度均明显高于对照组,血清炎症因子C反应蛋白、肿瘤坏死因子α、白细胞介素6含量低于对照组,2组差异均有统计学意义(P<0.05)。结论:阿托伐他汀钙强化降脂治疗有助于改善心功能、缓解炎症反应,是治疗冠心病心绞痛的理想方法。更多还原

【Abstract】 OBJECTIVE: To investigate the effect of atorvastatin calcium intensive lipid-lowering therapy on coronary heart disease and serum markers in patients with coronary heart disease complicating angina pectoris. METHODS: The electronic medical records of 150 patients with coronary heart disease complicating angina pectoris treated with atorvastatin calcium in Lu’an Municipal Hospital of TCM between April 2013 and July 2014 were included in our study.All the patients treated routinely with coronary vasodilators,myocardial nutritional agents and anticoagulant therapy etc were randomized to receive either atorvastatin calcium intensive lipid-lowering therapy( observation group) or atorvastatin calcium routine lipid-lowering therapy( control group) of 75 cases each. The cardiac function and serum level of inflammatory factors in the two groups were compared. RESULTS: The levels of triglyceride and cholesterol in the observation group were significantly lower than in the control group,showing statistically significant differenes between the two groups( P < 0. 05),but the differences between the two groups in cardiac and hepatorenal functions were not statistically significant( P > 0. 05); the left ventricular ejection fraction,stroke volume,left ventricular shortening fraction of inner diameter,wall thickening,ventricular septal motion rate were significantly higher in the observation group than in the control group,and serum levels of inflammatory factors CRP,TNF-α and IL-6 were lower in the observation group than in the control group,and the differences between the two groups were all statistically significant( P > 0. 05). CONCLUSIONS: Atorvastatin calcium intensive lipid-lowering therapy can help improve cardiac function and alleviate inflammatory reaction,which thus is the ideal therapy for angina pectoris.更多还原