【摘要】 目的观察依帕司他联合甲钴胺治疗糖尿病周围神经病变的疗效。方法将80例患者随机分为治疗组和对照组,各40例。在治疗糖尿病的同时,治疗组加用依帕司他50 mg口服、每日3次,甲钴胺500μg口服、每日3次;对照组予甲钴胺500μg口服,每日3次。均以12周为1个疗程。结果治疗组总有效率为92.50%,明显高于对照组的72.50%(P<0.05),两组神经传导速度差异有统计学意义(P<0.01),未出现明显不良反应。结论依帕司他联合甲钴胺治疗糖尿病周围神经病变疗效确切。更多还原

【Abstract】 Objective To evaluate the clinical efficacy of epalrestat and Methycobal combined therapy in treating diabetic peripheral neuropathy( DPN). Methods 80 cases of peripheral neuropathy and type 2 diabetes were randomly separated into an experiment group and a control group,40 cases of each group. The normal treatment of diabetes was used in two groups,members in the experiment group were treated with methycobal 500 μg,3 times one day. and epalrestat 50 mg,3 times one day; members in the control group were treated with methycobal 500 μg,3 times one day. At the end of 12 weeks,therapeutic courses,motor nerve conduction velocity( MNCV) and sural nerve conduction velocity( SNCV) were evaluated. Results The overall effective rate was 92. 50% in the experiment group and72. 50% in the control group, showing significant different between the two groups( P < 0. 05). The post therapeutic values of both SNCV and MNCV were significantly difference from those of previous treatment( P < 0. 01). No evidently relative adverse effects were observed in both groups. Conclusion Combined therapy of epalrestat and Methycobal was more effective in controlling the clinical activity to diabetic peripheral neuropathy.更多还原