【摘要】 目的观察氧化槐果碱的抗惊厥、抗炎作用。方法构建异烟肼和尼可刹米致小鼠惊厥模型,观察氧化槐果碱的抗惊厥作用;采用二甲苯致小鼠耳肿胀法和角叉菜胶致大鼠足跖肿胀法,观察氧化槐果碱的抗炎作用。结果氧化槐果碱(20,40,80mg/kg)可显著延长异烟肼所致惊厥小鼠的惊厥潜伏时间(P<0.05),减少惊厥小鼠例数与死亡小鼠例数,对尼可刹米所致的惊厥无对抗作用;氧化槐果碱(40,80mg/kg)可显著抑制二甲苯所致小鼠耳肿胀(P<0.05);氧化槐果碱(60mg/kg)可显著抑制角叉菜胶所致大鼠足跖肿胀(P<0.01),氧化槐果碱(30mg/kg)对致炎后2~4h的大鼠足跖肿胀有抑制作用。结论氧化槐果碱具有抗惊厥、抗炎作用。更多还原

【Abstract】 Objective To observe the effect of oxysophocarpine on anti-convulsion and anti-inflammatory.Methods The effect of oxysophocarpine on anti-convulsion was observed by constructing the isoniazide and carrageenin induced convulsion mouse model and the effect of oxysophocarpine on anti-inflammation was observed by the xylene-induced mouse ear swelling method and the car-rageenan induced rat toe swelling method.Results Oxysophocarpine(20,40,80mg/kg) could significantly prolong the isoniazide-in-duced latent period of convulsion(P<0.05),reduced the death cases and convulsion cases in mice.Oxysophocarpine had no effect on nikethamide-induced convulsion.Oxysophocarpine(40,80 mg/kg) could inhibit the xylene-induced ear swelling(P<0.05).Oxysophocarpine(60mg/kg) could inhibit the carrageenan-induced mouse toe swelling(P<0.01).Oxysophocarpine(30mg/kg) had the inhibiting effect on the carrageenan-induced toe swelling at 2-4h after induced inflammation.Conclusion Oxysophocarpine has certain anti-convulsion and anti-inflammatory effect.更多还原