【摘要】 目的研究应用选择性头部亚低温治疗出生6~12 h新生儿缺氧缺血性脑病临床疗效。方法运用随机抽样的方法选取2013年1月~2014年9月中山市博爱医院新生儿科收治的出生6~12 h发生缺氧缺血性脑病的新生儿80例,依据随机数字表法将其分为研究组和对照组,每组各40例。对照组患儿给予常规治疗,研究组患儿在常规治疗基础上加选择性头部亚低温治疗。统计分析两组患儿的NSE浓度、神经发育评分大运动DQ值、CR发生情况。结果研究组患儿1、2、3 d的NSE浓度均显著低于对照组(P<0.05),神经发育评分大运动DQ值显著高于对照组(P<0.05),脑瘫率(27.5%)显著低于对照组(52.5%)(P<0.05)。结论应用选择性头部亚低温治疗出生6~12 h新生儿缺氧缺血性脑病临床疗效显著。更多还原

【Abstract】 Objective To study the clinical efficacy of selective head hypothermia in the treatment of born 6-12 h neonatal hypoxic-ischemic encephalopathy.Methods 80 cases of birth 6-12 h occurred neonatal hypoxic-ischemic encephalopathy who were treated in Boai Hospital of Zhongshan City from January 2013 to September 2014 were selected,these children were divided into study group and control group by random sampling method,40 cases in each group.Children of the control group were given conventional treatment,while children of the study group were given selective head hypothermia treatment on the basis of conventional therapy,then the NSE concentration,neurodevelopmental scores big sports DQ value,the occurrence of serious adverse outcomes of children in the two groups were analyzed.Results The 1,2,3 d NSE concentrations of children in the study group were significantly lower(P < 0.05),the neurodevelopmental scores big sports DQ value was significantly higher(P < 0.05),the rate of serious adverse outcomes(27.5% ) was significantly lower than the control group(52.5% )(P < 0.05).Conclusion The clinical application efficacy of selective head hypothermia is significant in the treatment of born 6-12 h neonatal hypoxic-ischemic encephalopathy.更多还原