【摘要】 肥胖是一个国际公共卫生问题,其增加了许多慢性疾病(如糖尿病、心血管疾病)的发病风险,也是癌症包括胃癌在内的主要危险因素。肥胖可能通过胃食管反流、胰岛素抵抗、高胰岛素样生长因子及瘦素水平升高、脂联素表达过低、性激素水平改变等引起胃癌发生。幽门螺杆菌感染可导致消化系统及非消化系统疾病,目前研究发现,其与肥胖也密切相关。健康的饮食习惯和体力活动有利于预防肥胖,药物和手术治疗也是控制肥胖的方法。更多还原

【Abstract】 Obesity is a public health problem in the world,which increases the risk of many chronic diseases such as diabetes and cardiovascular diseases. Meanwhile,obesity is one of major risk factors for several types of cancers including gastric cancer. Possible mechanisms between obesity and gastric cancer include:gastro-oesophageal reflux,insulin resistance and high insulin-like growth factor( IGF) and leptin level increase,under-expression of adiponectin,and sex hormone level changes. Helicobacter pylori( Hp) infection leads to many digestive diseases and extradigestive diseases,and current studies show that Hp infection is correlated with obesity closely as well. Healthy dietary patterns and physical activity are beneficial for preventing obesity. Drug and surgical treatment are other methods available for obesity.更多还原