【摘要】 寻找有效的肿瘤干预靶点对肿瘤患者具有重要意义。蛋白质精氨酸甲基转移酶(PRMTs)是催化蛋白质底物精氨酸残基甲基化的唯一关键酶,参与多种重要的基础细胞代谢过程。近年来的研究发现,异常表达的PRMTs可以通过促进催化精氨酸残基甲基化的过程参与肿瘤的发生与发展;PRMTs表达的高低可以作为判断肿瘤预后的因子。这些结果提示,如果针对性干预PRMTs或许可以给肿瘤患者带来临床获益。更多还原

【Abstract】 Finding an effective intervention cancer target is important for the patients. Protein arginine methyltransferases( PRMTs) are the unique and critical enzymes which catalyze the methylation of protein substrates arginine residues,participate in a variety of important basic cell metabolic processes. Recent studies have found that PRMTs take part in the occurrence and development of cancer via promoting catalyzing the methylation of arginine residues,and the expression level of PRMTs can serve as a prognosis evaluating factor for cancer. These results indicate that it may bring clinical benefits to the tumor patients through targeted intervention of PRMTs.更多还原