【摘要】 目的探讨降钙素原对诊治脑出血微创术后合并颅内感染的影响。方法选取开封市第二人民医院2011年6月至2013年6月脑出血微创术后疑似颅内感染患者77例作为研究对象,采集血样分析降钙素原水平,同时留取脑脊液行细菌学培养,观察脑脊液常规、脑脊液生化和血白细胞计数的检查结果。根据是否合并感染分为感染组(30例)以及非感染组(47例)。对感染组患者常规治疗1周后重新测定降钙素原值。结果感染组降钙素原水平显著高于非感染组[(5.67±2.30)μg/L比(0.55±0.29)μg/L,P<0.01]。两组脑脊液常规、脑脊液生化和血白细胞计数水平比较,差异无统计学意义(P>0.05)。治疗后,确诊为颅内感染的30例患者24例感染得到控制,6例死亡。24例患者平均降钙素原水平由治疗前(5.53±2.31)μg/L下降为(1.25±0.23)μg/L(P<0.05)。结论降钙素原水平在微创术后合并颅内感染患者血清内会显著增高,并且患者感染得到控制时会显著下降,具有较高的特异性,可作为一种颅内感染的早期诊断影响指标以及预后的评估指标。更多还原

【Abstract】 Objective To investigate the effects of procalcitonin( PCT) in the diagnosis and treatment of intracranial infection after cerebral hemorrhage minimally invasive surgery. Methods A total of 77 patients with suspected intracranial infection after cerebral hemorrhage minimally invasive surgery treated in Kaifeng Second People’s Hospital from Jun. 2011 and Jun. 2013 were selected as research objects,blood samples of the patients were collected to analyze the PCT levels; meanwhile,cerebrospinal fluids( CSF) were sampled for bacteriological culturing,results of CSF routine test,CSF biochemical test and white blood cell( WBC) count were observed. According to the above results,patients were divided into infection group( 30 cases) and noninfection group( 47 cases). Patients in the infection group were routinely treated for a week,and then the PCT values were re-determined. Results The PCT level of the infection group was significantly higher than that of the non-infection group,and the difference was statistically significant[( 5. 67 ± 2. 30) μg / L vs( 0. 55 ±0. 29) μg / L,P < 0. 01]. The differences of CSF routine test,CSF biochemical test and blood WBC count results between the two groups were not statistically significant( P > 0. 05). After the therapy,24 cases out of the 30 patients definitely diagnosed with intracranial infection got controlled,and the average PCT level was decreased from( 5. 53 ± 2. 31) μg / L before the therapy to( 1. 25 ± 1. 23) μg / L( P < 0. 05). Six patients died. Conclusion PCT level is significantly increased in the serum of patients with intracranial infection after cerebral hemorrhage minimally invasive surgery and significantly decreased after the infection is controlled,with high specifity,and consequently it can be used as an index for early diagnosis and prognosis evaluation of intracranial infection.更多还原