【摘要】 子痫前期以新发的高血压和蛋白尿为特征,是一种严重的妊娠合并症。其发病机制涉及氧化应激、内皮功能失调、血管收缩、代谢改变、血栓性疾病及免疫反应等。目前的主流观点认为,子痫前期是与遗传和环境因素相关的多基因疾病,并且越来越多的研究发现,母体和胎儿的遗传基因改变是子痫前期发病的重要因素。更多还原

【Abstract】 Preeclampsia is characterized by newly onset hypertension and proteinuria and is a major pregnancy complication. The pathogenesis involves oxidative stress,endothelial dysfunction,vasoconstriction,metabolic changes,thrombotic disease and immune response,etc. At present the mainstream view is that preeclampsia is a polygenic disease associated with genetic and environmental factors,and a growing number of studies have found that maternal and fetal genetic change is an important factor in the pathogenesis of preeclampsia.更多还原