【摘要】 Hippo信号通路首先在果蝇属中发现,在哺乳动物高度保守,通过调节细胞增殖和凋亡维持器官大小和机体内环境的稳态。Yes相关蛋白(YAP)是Hippo信号通路的关键效应分子,作为转录共激活因子扮演着癌基因和抑癌基因的矛盾角色。YAP去磷酸化后活化,入核参与细胞增殖和凋亡的调节;其中涉及哺乳动物雷帕霉素靶蛋白(m TOR)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、Wnt/β联蛋白(Wnt/β-catenin)等信号通路。该文对哺乳动物Hippo-YAP信号通路调节细胞增殖和凋亡作用机制的研究进展予以综述。更多还原

【Abstract】 Hippo signaling pathway was first discovered in Drosophila,and was highly conservative in mammalian. It governs organ sizes and internal environment homeostasis through regulation of cell proliferation and apoptosis. YAP is the key effector in Hippo signaling pathway,as a transcriptional coactivator plays a contradictory role of oncogenes and tumor suppressor genes. YAP is activated by dephosphorylation in the nucleus,then regulates the cell proliferation and apoptosis,which involves m TOR,PI3K-Akt,Wnt/β-catenin signaling pathways. Here is to make a review of the mechanisms of mammalian Hippo-YAP signaling pathway in the proliferation and apoptosis.更多还原