【摘要】 糖尿病肾病(DN)是2型糖尿病患者最常见的微血管并发症之一,也是导致终末期肾病的主要原因。现已认识到肥胖与2型糖尿病的发病显著相关。肥胖与糖尿病一样,是一种多因素、多基因性疾病,与生活方式密切相关。多种类型的肥胖中以腹型肥胖与糖尿病的发生关系最为密切。肥胖患者常伴有胰岛素抵抗,而后者是DN发生的始动因素。肥胖可促使多种脂肪因子、炎性因子的产生,通过多种机制影响糖尿病肾脏的病理生理及脂质代谢,促使DN的发生。更多还原

【Abstract】 Diabetic nephropathy( DN) is one of the most common microvascular complications in patients with type 2 diabetes and the main cause for end-stage renal disease. It has been considered that obesity is significantly associated with the onset of type 2 diabetes. Just as diabetes,obesity is a disease caused by multiple factors and polygenic disorder,and it is closely associated with the life style. Among various types of obesity,abdominal obesity has the closest correlation with the incidence of diabetes. Obese patients are always complicated by insulin resistance,which is the initiating factor of DN. Obesity can accelerate the production of various fat factors and inflammatory factors,affect the pathophysiology and lipid metabolism of diabetic kidney through a variety of mechanisms,and finally lead to the incidence of DN.更多还原