【摘要】 目的观察脑缺血预适应(BIP)对急性脑梗死患者病情及预后的影响。方法选取2008年10月至2012年5月在唐山市人民医院神经内科住院治疗的127例急性脑梗死患者,根据发病前1周内有无短暂性脑缺血发作(TIA)发病史分为观察组(有TIA史)(65例),对照组(无TIA史)(62例),观察两组临床疗效及治疗后梗死病灶大小、神经功能缺损评分等指标。结果观察组梗死病灶显著小于对照组[(14±8)m L比(21±11)m L](P<0.05);神经功能缺损评分显著低于对照组[(18±6)分比(24±8)分](P<0.05);观察组治疗总有效率(84.6%)显著高于对照组(69.4%)(P<0.05)。结论 BIP可增加急性脑梗死组织对缺血损害的耐受性,并产生神经保护作用。更多还原

【Abstract】 Objective To observe the influence of brain ischemic preconditioning( BIP) on the condition and prognosis of patients with acute cerebral infarction. Methods A total of 127 patients with acute cerebral infarctionadmitted in Tangshan People’s Hospital from Oct. 2008 to May 2012 were selected,and divided into the observation group( 65 cases,with a history of TIA) and the control group( 62 cases,with no TIA history) according to the presence of transient ischemic attack( TIA) history within 1 week before the onset.The clinical curative effects and indicators such asinfarction lesion sizes and neural function defect scales of two groups after treatment were observed. Results The infarction lesion size of the observation group was significantly less than that of the control group [( 14 ± 8) ml vs( 21 ± 11) ml]( P < 0. 05),and the nerve function defect scale of the observation group was significantly lower than that of the control group( 18 ± 6 vs24 ± 8)( P < 0. 05). The total effective rate of the observation group( 84. 6%) was significantly higher than that of control group( 69. 4%)( P < 0. 05). Conclusion BIP can increase the toleration of acute cerebral infarction tissues to ischemia injury,and generate nerve protective effect.更多还原