【摘要】 子宫内膜异位症(EMs)恶变可发生于卵巢和非卵巢部位,发生于卵巢者称为EMs相关性卵巢癌。目前为止,卵巢EMs恶变的病因尚不清楚。该文主要从癌基因和抑癌基因、细胞凋亡、雌激素及其受体调节、免疫及炎症改变以及氧化应激等5个方面对卵巢EMs恶变的病因进行了阐述。此外,信号转导途径异常、纤维酶原激活系统异常、二口恶英、遗传因素等也可能参与了卵巢EMs恶变。更多还原

【Abstract】 Endometriosis( EMs) malignant transformation can occur in ovary and non-ovary position. Endometriosis associated ovarian cancer is classically defined as the malignant transformation of endometriosis in the ovaries. Until now,the pathogenesis by which endometriosis associated ovarian carcinoma develops remain poorly understood. Here is to review the current data regarding the pathogenesis of endometriosis malignant transformation associated with oncogenes and tumor suppressor genes,apoptosis,estrogen and its receptors regulation,immune and inflammatory responses and oxidative stress. In addition,EMs associated ovarian cancer may be connected to abnormal signal transduction pathways,fiber enzyme activation system anomalies,dioxin and genetic factor as well.更多还原