【摘要】 赖氨酸特异性去甲基化酶1(LSD1)是第一个被发现的赖氨酸特异性脱甲基酶,其可以特异地去除组蛋白H3第4位赖氨酸(H3K4)和组蛋白H3第9位赖氨酸(H3K9)的二甲基和一甲基修饰,调控靶基因的表达。LSD1在肿瘤的发生、增殖、侵袭转移过程中均发挥了重要作用,有望成为肿瘤治疗的新的分子靶标。本文就LSD1在肿瘤领域的研究进展作一综述。更多还原

【Abstract】 Lysine-specific demethylase 1(LSD1),the first discovered histone demethylase,can specifically catalyze the demethylation of mono-and dimethylated histone H3 lysine 4(H3K4)and H3 lysine 9(H3K9),and regulate the expression of its target genes.LSD1 play important roles in proliferation,migration and invasion of various cancer cells,and it promises to be new molecular targets in cancer therapy.Thus,the authors address the related issues along with research progress of LSD1 associated with carcinoma.更多还原