【摘要】 目的观察并评价胆汁胰液混合液在体外对颈动脉粥样硬化斑块的溶解效果。方法把手术取出的颈动脉粥样硬化斑块分为不稳定斑块与稳定斑块,在37℃下分别加入新鲜胆汁胰液混合液,观察并记录二者在胆汁胰液混合液中的溶解情况。结果不稳定斑块和稳定斑块内层的脂质核心均可迅速被胆汁胰液混合液软化溶解,而外层的纤维帽则均不被溶解。不稳定斑块因脂质核心占比大而溶解效果显著,而稳定斑块因其脂质核心小,溶解效果相对较差。结论本研究发现胆汁胰液混合液中的某种或某几种成分对颈动脉粥样硬化斑块有一定的溶解作用,本研究尝试提出可能的溶解机制,并在下一步探究胆汁胰液混合液中溶解颈动脉粥样硬化斑块的有效成分。更多还原

【Abstract】 Objective To evaluate the effectiveness of in vitro dissolution of carotid atherosclerotic plaques with the mixed bile and pancreatic juice. Methods We divided the carotid plaques into unstable plaques and stable plaques,added the fresh mixed bile and pancreatic juice respectively at a temperature of 37℃,observed and recorded the two dissolved in the mixed bile and pancreatic juice. Results The lipid- rich necrotic core within unstable or stable plaques was dissolved quickly by bile,while other components,including the fibrous cap,cannot be dissolved. The large lipid- rich core of unstable plaque accounted for more significant dissolution than in stable plaque. Conclusion We found that the mixed bile and pancreatic juice lytic effect on carotid atherosclerotic plaque. We tried to suggest possible dissolution mechanism. The next research may be analysing what kinds of ingredients can play a role in softening and dissoluting carotid atherosclerotic plaque.更多还原