【摘要】 目的探讨经手术治疗的宫颈鳞癌患者治疗前中性粒细胞与淋巴细胞比(neutrophil-tolymphocyte ratio,NLR)及血小板与淋巴细胞比(platelet-to-lymphocyteratio,PLR)与总生存期(overall survival,OS)、无病生存期(disease-free survival,DFS)和各临床病理因素的相关性。方法回顾性分析中山大学附属第一医院于2005年1月1日至2009年12月31日期间初治的并且经过手术治疗的143例宫颈鳞癌患者的临床病理资料,根据统计学方法选取NLR和PLR截断值,将患者根据截断值分组,分析NLR和PLR与患者生存、复发情况的相关性以及与临床病理因素的相关性。结果选取NLR=2.8和PLR=125分别作为截断值,高NLR组5年生存率为30.3%,低NLR组5年生存率为80%,差异有统计学意义(P=0.000)。高NLR组复发率为69.7%,低NLR组复发率为24.5%,差异有统计学意义(P=0.000)。高PLR组5年生存率为53.7%,低PLR组5年生存率为81.6%,差异有统计学意义(P=0.000)。高PLR组复发率为50%,低PLR组复发率为22.4%,差异有统计学意义(P=0.000)。经过单因素和多因素分析,国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期、术前化疗、病灶大小、外周血血小板计数(platelet,PLT),NLR值和PLR值是影响宫颈鳞癌患者总生存率和无病生存率的独立危险因素。结论治疗前NLR及PLR均是影响宫颈鳞癌患者总生存时间和无病生存时间的独立危险因素。更多还原

【Abstract】 Objective To investigate the correlation between neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyteratio(PLR) from pre-treatment and clinical parameters including overall survival(OS), disease-free survival(DFS) and clinical pathologic factors in the patients with cervical squamous cell carcinoma. Methods In this retrospective analysis from January 1, 2005 to December 31, 2009, 143 cases of cervical squamous carcinoma patients were collected, which were firstly treated and undergone surgery in the first affiliated hospital of Sun Yat-sen university. According to the statistical methods, the patients weredivided into different groups based on the cut-off value of NLR or PLR. Then the relationship between NLR and PLR with the survival and recurrence situation of patients and the the factors of clinical and pathological were analyzed. Results NLR=2.8 and PLR=125 were selected as the cut-off value. The 5-year survival rate of high NLR group is 30.3%, while the 5-year survival rate of low NLR group is 80%, and the difference was statistically significant(P =0.000). The recurrence rate of high NLR group is 69.7%, while in low NLR group is 24.5%, and the difference was statistically significant(P =0.000). The 5-year survival rate of high PLR group is 53.7%, while the 5-year survival rate of low PLR group is 81.6%, and the difference was statistically significant(P =0.000). The recurrence rate of high PLR group is 50%, while in low NLR group is 22.4%, and the difference was statistically significant(P =0.000). Univariate analysis and Cox regression analysis all showed that International Federation of Gynecology and Obstetrics(FIGO) stage, preoperative chemotherapy, the tumor size, platelet(PLT), NLR and PLR are all independent prognostic factors for overall survival rate and disease-free survival rate in cervical squamous cell carcinoma patients. Conclusion NLR and PLR values from pre-treatment are independent prognostic factor for cervical squamous cell carcinoma patients, respectively.更多还原