【摘要】 从川桑树枝的95%乙醇提取物中分离得到1个新的黄酮类化合物,命名为notabilisin K(1),4个已知黄酮类化合物,分别为morusin(2)、mulberrofuran A(3)、neocyclomorusin(4)和mornigrol F(5),化合物2~5均为首次从该植物中分离出来。notabilisin I和notabilisin J对HCT-116、Hep G2、A2780细胞有一定的杀伤作用,IC50为1.47~5.46μmol·L-1;Morusin对5种人肿瘤细胞(BGC823、A2780、HCT-116、Hep G2和NCI-H1650)都有较强的杀伤作用,IC50为0.74~1.58μmol·L-1。更多还原

【Abstract】 One new flavonoids named as notabilisin K(1), together with four known compounds, morusin(2), mulberrofuran A(3), neocyclomorusin(4) and mornigrol F(5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, Hep G2 and A2780 with IC50 values ranging from 1.47 μmol·L-1 to 5.46 μmol·L-1. Morusin exhibits strong effect against five kinds of human cancer cells(BGC823, A2780, HCT-116, Hep G2 and NCI-H1650) with IC50 values ranging from 0.74 μmol·L-1 to 1.58 μmol·L-1.更多还原