【摘要】 目的探讨ω-3鱼油脂肪乳(ω-3 PUFA)治疗活动性梗阻型克罗恩病的临床效果。方法选取2010年10月至2013年10月本院收治的活动性梗阻型克罗恩病患者80例作为研究对象,根据患者采用肠外营养联合糖皮质激素或ω-3 PUFA将其分为对照组和研究组,每组各40例。比较两组患者诱导缓解治疗情况、并发症发生情况和耐受全肠内营养时间。结果对照组患者诱导缓解治疗时间为(32.1±0.6)天,诱导成功例数为28例,克罗恩病活动指数(CDAI)评分为(107.8±23.5)分,C反应蛋白(CRP)水平为(7.8±0.8)mg/L,与研究组比较差异均具有显著性(P<0.05)。研究组患者并发症发生率为12.5%(5/40),明显低于对照组[30.0%(12/40)],耐受全肠内营养时间为(25.02±0.83)天,明显少于对照组[(30.28±1.37)天],差异均具有显著性(P<0.05)。结论与肠外营养联合糖皮质激素相比,肠外营养联合ω-3 PUFA的诱导缓解治疗时间更短,成功率更高,并发症更少,对活动性梗阻型克罗恩患者的治疗效果更好,值得临床推广应用。更多还原

【Abstract】 Objective To explore the application results of the Omega-3 polyunsaturated fatty acid(ω-3 PUFA) therapeutic in active obstruction type Crohn’s disease. Method 80 patients with active obstruction type Crohn’s disease were selected from October 2010 to October 2013 in our hospital, and divided into control group and study group according to parenteral nutrition combined with GCS or ω-3 PUFA, 40 cases in each group. Compared two groups of patients with remission induction therapy, complications, total enteral nutrition time. ResultThe remission induction treatment time in the control group was(32.1±0.6) days, the number of cases for the successful induction was 28 cases, CDAI score was(107.8±23.5) points, CRP was(7.8±0.8) mg/L, compared with study group, the differences were significant(P < 0.05). The complication rate in study group was 12.5%(5/40), significantly lower than control group [30.0%(12/40)], total enteral nutrition time was(25.02±0.83) days, significantly less than control group [(30.28±1.37) days], the differences were statistically significant(P < 0.05). Conclusion Compared with parenteral nutrition combined with GCS, ω-3 PUFA combined with parenteral nutrition has shorter remission treatment times, higher success rates, fewer complications, the treatment effect in patients with active obstruction type Crohn’s disease more good, worthy of clinical application.更多还原