【摘要】 目的比较单纯伽玛刀(GKRT)和IMRT全脑同步放疗或缩野推量技术治疗肺癌脑转移瘤的临床疗效。方法回顾分析我院2008年1月—2014年1月收治的76例肺癌脑转移瘤患者,54例初治行伽玛刀治疗,22例初治行IMRT全脑放疗同步或缩野推量技术治疗。结果 GKRT组近期客观有效率为85.2%,不良反应率14.8%,中位生存时间11个月;IMRT组近期客观有效率为77.3%,不良反应率36.4%,中位生存时间10个月。结论伽玛刀治疗肺癌脑转移瘤安全有效,并发症少,生存期长,可作为肺癌脑转移瘤的主要治疗手段。更多还原

【Abstract】 Objective To investigate the effect of Gamma Knife(GKRT)and IMRT boost(SIB or SB)technique for brain metastases from lung cancer. Methods From January 2008 to January 2014,99 lung cancer patients with brain metastases received GKRT or IMRT(SIB or SB-IMRT).The initial treatment for 71 cases was GKRT,and for other28 cases was IMRT. Results The follow-up of 76 cases was effective. In GKRT group,the objective response rate(ORR)was 85.2%,the adverse reaction rate was14.8%,the median survival time was 11 months. In IMRT group,the objective response rate was 77.3%,the adverse reaction rate was 36.4%,the median survival time was 10 months.Conclusions Compared with IMRT boost,Gamma Knife is safe and effective for brain metastases from lung cancer,with fewer complications and longer survival.It can be used as the main treatment for brain metastases from lung cancer.更多还原