【摘要】 大环内酯类抗生素广泛用于治疗呼吸道感染,但日益泛滥的大环内酯耐药菌正影响着公众的健康。为了解决这一问题,科研工作者对大环内酯类化合物进行了大量的结构修饰。综述近年来对红霉素衍生物C6位进行的结构改造及对其生物活性的影响。更多还原

【Abstract】 Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections.However,the increasing prevalence of macrolide-resistant pathogens poses a serious risk to public health.To overcome the issue of drug resistance,numerous modifi cations have been made on macrolides.The recent development in structural modifi cations on C6 of erythromycin derivatives and the impact to biological activity was reviewed.更多还原