【摘要】 目的观察乙肝疫苗(HBVac)与乙肝免疫球蛋白(HBIG)联合阻断HBV母婴传播效果。方法采用HBVac和HBIG,对芒市乙肝表面抗原(HBs Ag)阳性产妇分娩的新生儿实施母婴阻断措施。结果 2011年1~6月,检测在芒市各医院住院分娩产妇的HBs Ag 2821例,阳性73例,阳性率2.59%。按项目方案对73名婴儿实施乙肝母婴阻断措施,HBVac全程免疫率100%;HBIG免疫率86.30%;实施后检测婴儿血清73份,HBs Ag阳性1份,阳性率1.37%;HBSAb阳性72份,阳性率98.63%;HBe Ag阳性4份,阳性率5.48%;乙肝母婴阻断成功率94.52%。结论应用HBVac联合HBIG能有效阻断HBV的母婴垂直传播,对防治乙型肝炎具有指导意义。更多还原

【Abstract】 Objective To observe the HBVac( Hepatitis B Vaccine) affiliate HBIG( Hepatitis B Immune Globulin) interrupt HBV( hepatitis b virus) effect in maternal- neonatal transmission. Methods HBVac and HBIG were used to interrupt the neonate with HBs Ag( Hepatitis B Surface Antigen) positive mother in Mangcity. Results From January to June in 2011,2821 puerperas were found in Mang city,73 positive cases,positive rate of 2. 59%. 73 neonates were interrupted using HBVac and HBIG. 100% HBVac and 86. 30%HBIG immunization rate respectively according to the plan; after implementation,detected 73 neonate serum;HBs Ag positive 1,the positive rate was1. 37%; HBSAb positive 72,the positive rate was 98. 63%; HBe Ag positive 4,the positive rate was 5. 48%; The success rate of HBV interruption in maternal- neonatal transmission was 94. 52%. Conclusions HBVac affiliate HBIG not only can interrupt the HBV infection through maternal- neonatal transmission effectively but also helpful for prevention and cure HBV.更多还原