【摘要】 目的了解邯郸市无偿献血者HIV感染的情况,保障血液安全,降低输血传播HIV的风险。方法对邯郸市2002-2013年672 866人次献血者样本采用2种不同厂家的ELISA试剂检测抗-HIV,对于1种或2种试剂有反应性的样本判为HIV初筛阳性,送邯郸市CDC实验室采用WB法进行确证实验。对初筛和确证结果进行统计分析。结果邯郸市无偿献血人群抗-HIV初筛阳性率年度间差异有统计学意义(P<0.01);HIV确证感染者24例,不确定者21例,年均感染率为0.36/万,年度感染率有增加的趋势;HIV感染者男性明显多于女性;18~40岁占多数(79.2%);文化程度以初中和高中居多;外地户籍与本地户籍比例为9:15;职业中以其他和农民居多。大部分经性传播,MSM感染者占半数以上;感染者多数为初次献血。WB法确证阳性者均为HIV-1型感染,未发现HIV-2型感染。WB带型全带的占41.7%,gp160、gp120、p41、p24出现率为100.0%,其次分别是p66(87.5%)、p51(79.2%),单带p55和p39出现率分别为54.2%、50.0%。HIV不确定者WB带型出现最多的是p24(81.7%),其次分别是gp160(25.6%)、p17(9.5%)、gp41(4.8%)。结论邯郸市献血人群HIV感染率有逐年增加的趋势,感染者具有男性多、年轻化、学历低、职业流动性大的特点,血液安全面临形势严峻,应加强固定献血队伍的建设,注重多方面采取措施降低经血传播HIV的风险。更多还原

【Abstract】 Objective Understanding of unpaid blood donors with HIV of Handan city,to ensure the safety of blood,reduce the risk of blood transfusion spread HIV. Methods Using ELISA reagent testing anti-HIV that comes from 2different manufacturers for 672866 blood samples of Handan city during 2002-2013,determined for early screening HIV positive for 1 or 2 kinds of reagents with reactive samples,tested and confirmed by WB method by send to city CDC laboratory. Initial screen and confirmed results for statistical analysis. Results There was statistically significant differences( P <0. 01) of unpaid blood donation population preliminary anti-HIV screening in Handan city between years; 24 cases of confirmed HIV infected people,un confirmed 21 cases,the average yearly infection rate is 0. 36 /10000,annual infection rate has a tendency to increase; HIV male infectors were significantly higher than females; the majority were 18-40 years old( 79. 2%); majority cultural degrees were junior and senior high school; proportion is 9:15 of non-local census register with the locals; profession majority were other and farmers. Most were through sexual transmission,MSM infection accounted for more than half; Most infected people were donate blood for the first time.WB method confirmed positive for HIV-1 type of infection,no HIV-2 type infection found. WB method confirmed positive were all HIV-1 accounted for 41. 7%,gp160,gp120,p41,and p24 presence rate was 100%,followed by p66( 87. 5%),p51( 79. 2%),single p55 and p39 were 54. 2% and 50. 0% respectively. HIV non confirmed appear WB belt type mostly was p24( 81. 7%),followed by gp160( 25. 6%),p17( 9. 5%),and gp41( 4. 8%). Conclusions Blood donation population of HIV infection rate has increased year by year trend in Handan city,the characteristics of infected are more male,younger,low education degree and big job mobility,blood safety facing a tough situation,should strengthen the construction of regular blood donation team,pay attention to the various measures to reduce the risk of blood transmission of HIV.更多还原