【摘要】 目的:了解佛山市顺德区首次美沙酮门诊吸毒人员HIV、HBV、HCV和梅毒感染状况及其危险因素。方法:对2006年1月-2013年12月893名首次进行美沙酮门诊吸毒人员进行HIV、HCV、梅毒抗体及HBV抗原进行检测,同时进行问卷调查。结果:893名吸毒者中HIV抗体、HCV抗体、梅毒抗体、HBV抗原阳性率分别为2.24%(20/893)、69.54%(621/893)、0.90%(8/893)、20.94%(187/893),男性吸毒者血清HIV、HCV、梅毒和HBV的阳性检出率分别为1.75%、70.05%、0.75%、21.30%,女性吸毒者血清HIV、HCV、梅毒和HBV的阳性检出率分别为6.31%、65.26%、2.11%、17.89%,女性HIV阳性率显著高于男性(P<0.05),男性HCV、HBV及梅毒的感染与女性无统计学差异(P>0.05)。多个性伴侣吸毒人群HIV、HCV阳性率显著高于单个性伴侣人群(P<0.05)。其中静脉吸毒者556例,非静脉吸毒者337例,静脉吸毒HCV感染率83.81%,明显高于非静脉吸毒感染率46.0%(P<0.01)。静脉吸毒HIV抗体、梅毒抗体、HBV抗原阳性率分别为2.34%(13/556)、1.08%(6/556)、19.97%(111/556),非静脉吸毒HIV抗体、梅毒抗体、HBV抗原阳性率分别为2.08%(7/337)、0.59%(2/337)、22.55%(76/337),两组比较差别无统计学意义,P值分别为0.80、0.70和0.36。合并感染HCV、HBV病毒者15.34%(137/893),其中静脉吸毒19.60%(109/556),明显高于非静脉吸毒者8.31%(28/337),P值为0.00。结论:佛山市顺德区女性吸毒人员HIV感染率显著高于男性,静脉吸毒人群HCV感染率明显较非静脉吸毒人群高,静脉吸毒者合并HCV、HBV病毒感染率较高,多个性伴侣吸毒人群HIV、HCV感染率高。应采取综合干预措施控制HIV、HBV、HCV在吸毒人群中蔓延。更多还原

【Abstract】 Objective:To acquire the HIV,HBV,HCV and syphilis infection status and the risk factor in new clients of methadone clinics service in Shunde District of Foshan City.Methods:Antibody of HIV,HCV,syphilis and HBV antigen of the blood among 893 patients who accepted the first time methadone outpatient service in Shunde District of Foshan City from 2006 to 2013 were tested,and the questionnaire survey was investigated at the same time.Results:The positive rates of HIV,HCV,syphilis antibody and HBV antigen were 2. 24%( 20 /893),69. 54%( 621 /893),0. 90%( 8 /893),20. 94%(187 /893)in 893 drug users. Positive rates of HIV,HCV,syphilis antibody and HBV antigen in male drug users were 1. 75%,70. 05%,0. 75% and 21. 30%,as those in female were 6. 31%,65. 26%,2. 11% and 17. 89%. HIV antibody positive rate in female were significantly higher than in male( P <0. 05). The infection rates of HCV,HBV and syphilis showed no statistically difference between male and female. HIV and HCV- positive rates in drug users with multiple sexual partners were significantlyhigher than that of drug users with single sexual partner( P < 0. 05). Five hundred fifty six cases were used intravenous injection. The HCV infection rate of intravenous injection drug users was 83. 81%,and the infection rate was significantly higher than that in the non- intravenous injection drug users(46. 0%,P < 0. 01). The positive rate of HIV,syphilis antibody and HBV antigen in intravenous injection drug users were 2. 34%( 13 /556),1. 08%( 6 /556),19. 97%( 111 /556),as they were in the non-intravenous injection drug users were 2. 08%(7 /337),0. 59%(2 /337),22. 55%(76 /337),and the positive rates showed no statistically difference between the two groups( P = 0. 80,0. 70,0. 36). The co- infection rate of HCV and HBV was 15. 34%( 137 /893). It was 19. 60%( 109 /556) among intravenous injection drug users,and was significantly higher than in non- intravenous injection drug users( 8. 31%,28 /337,P = 0. 00).Conclusion: The HIV infection rate in females drug users was significantly higher than in males in methadone maintenance treatment patients of Shunde District of Foshan City. The HCV infection rate in intravenous injection drug users was significantly higher than that in non- intravenous injection drug users. The HCV and HBV co- infections in intravenous injection drug users was higher than that in non- intravenous injection drug users. HIV,HCV- positive rate was high in the drug users with multiple sexual partners. We should take comprehensive intervention measures to control the HIV,HBV,HCV and syphilis infection and spread in drug users.更多还原