【摘要】 目的:观察多奈哌齐对颅脑外伤后患者认知功能障碍的改善作用。方法:颅脑外伤后认知功能障碍住院患者76例随机分为观察组和对照组各38例。两组患者均予控制颅内压、神经营养及防治并发症等基础治疗。观察组患者加用多奈哌齐片5 mg,po qd;对照组患者加用脑复康片1.2 g,po tid。两组均连用2周。观察两组患者治疗前后认知功能指标的变化,比较两组疗效及药品不良反应。结果:治疗2周后,两组患者WMS评分和MOCA评分均较前明显上升(P<0.05或P<0.01),且观察组较对照组上升更明显(P<0.05);观察组患者认知功能总改善率为94.74%,明显高于对照组的76.32%(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:多奈哌齐对颅脑外伤后患者认知功能障碍具有良好的改善作用,能促进患者认知功能的恢复,且安全性较好。更多还原

【Abstract】 Objective: To discuss the effect of donepezil on cognitive impairment after craniocerebral trauma.Methods: 76 cases of patients with cognitive impairment were divided into observation group( 38 cases) and control group( 38 cases) at random. The patients in two groups were given control of intracranial pressure,nerve nutrition,preventive treatment of complication and other basic treatments according to the circumstances. The patients in observation group were additionally given donepezil tablsts 5mg per time,once a day,while the patients in control group were additionally given piracetam tablets 1. 2g per time,three times a day for 2 weeks. The changes of cognitive effect indexes of patients in two groups before and 2 weeks after the medical treatment were observed and recorded,and the clinical curative effect and adverse drug reactions( ADR) were compared as well. Results: After 2 weeks’ medical treatment,The WMS and MOCA scores of patients in two groups were rose obviously than before( P < 0. 05 or P < 0. 01),and the rising rate in observation group was much higher than that in control group( P < 0. 05). Meanwhile,total improvement rate of cognitive function of patients in observation group was 94. 74%,which was much higher than that in control group( 76. 32%,P < 0. 05). After comparing the ADR incidence of patients in two groups,no statistical differences were appeared( P > 0. 05). Conclusion:Donepezil had favorable improvement effect on cognitive impairment after craniocerebral trauma,which can improve the recovery of cognitive function of patients,with light untoward effect and high security.更多还原