【摘要】 目的:建立实验性大鼠牙周炎局部治疗模型,检测C反应蛋白(CRP),细胞间粘附分子-1(ICAM-1),E-选择素(E-selectin)在大鼠牙周组织及血清中的表达水平。方法:结扎6月龄SD大鼠双侧第一磨牙4周后,经临床检查和HE组织学切片确认牙周炎模型成功建立;结扎8周后去除结扎丝进行牙周基础治疗,分别于治疗4、8、12周取大鼠双侧上颌骨及股动脉血,检测CRP、ICAM-1、E-selectins在牙周组织中表达及血清中水平的变化。结果:局部治疗后,随着时间的延长,牙周组织的炎症和牙周破坏的程度减轻,牙周附着水平增加(P<0.05),牙周组织中和血清中的CRP、ICAM-1、E-selectin不断降低(P<0.05)。结论:牙周局部治疗可降低CRP、ICAM-1、E-selectin在牙周组织中的表达和血清中的水平。更多还原

【Abstract】 AIM: To study the expression changes of C reactive protein( CRP),intercellular adhesion molecule-1( ICAM-1) and E-selectin in periodontal tissue and in serum of rats with experimental periodontitis following local treatment. METHODS: Rat periodontitis model was established in 60 SD rats by periodontal ligation for 8weeks. Then the ligation was removed and local treatment was conducted,the expression level of of CRP,ICAM-1 and E-selectin in the periodontal tissue and in serum was measured at 4,8 and 12 weeks respectively after local treatment( n = 10). RESULTS: After local treatment the experimental periodontitis was eased( P < 0. 05),the expression lvel of CRP,ICAM- 1 and E- selectin in periodontal tissue and serum was decreased in a time dependent manner( P < 0. 05). CONCLUSION: Periodontal treatment can reduce the expression of CRP,ICAM-1 and E-selectin expression in periodontal tissues and serum.更多还原