【摘要】 目的 探讨四次甲基二砜四胺(TET)中毒患者血中毒物浓度测定的临床意义。方法 采用气相色谱法测定55例患者(中毒至入院时间0.5~3 h)入院时及第3日血中TET含量。计算入院前患者癫痫发作频率。采用速率法测定入院时及入院第3日血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)、α-羟丁酸脱氢酶(HBDH)浓度。入院第3日33例患者行脑电图检查。采用Pearson相关分析软件分析血中TET浓度及血清心肌酶浓度的相关性。采用Spearman秩相关分析软件分析入院时血中TET浓度与癫痫发作频率及第3日脑电图异常程度的相关性。结果 入院时血中TET浓度同癫痫发作频率、肌酸激酶浓度呈正相关;人院时血中TET浓度同血清乳酸脱氢酶、肌酸激酶同工酶、谷草转氨酶、α-羟丁酸脱氢酶浓度无相关性;入院时血中TET浓度同入院第3日血中TET浓度有相关性;入院第3日血中TET浓度同血清CK、CK-MB、LDH、AST、α-HBDH浓度无相关性;入院时血中TET浓度同脑电图异常程度无相关性;入院第3日血中TET浓度同脑电图异常程度呈正相关。结论 入院时及入院第3日血中TET浓度可作为衡量病情轻重的重要参考指标。更多还原

【Abstract】 Objective To evaluate the clinical significance of serum tetramethylenesulphotetramine(TET)concentration in patients with TET poisoning.Methods Fifty-five patients,25 males and 30 females,aged 1.3 ~81 were admitted 0.5~3 h after they took TET orally.Samples of peripheral blood were collected on admission and 3days after admission.Gas chromatography was used to measure the serum TET concentration,and automatic clinical chemistry analyzer was used to detect the concentrations of the myocardial enzymes:creatine kinase(CK),creatine kinase-MB(CK-MB),lactate dehydrogenase(LDH),aspartate transaminase(AST),and α-hydroxybutyrate dehydrogenase(a-HBDH).Electroencephalography was performed on 33 patients 3 days after admission.Pearson correlation analysis was used to analyze the correlation of TET with the concentrations of the myocardial enzymes.Spearman rank correlation analysis was used to analyze the correlation of blood TET with the epilapsy seizure rate and EEG abnormality.Results The blood TET concentration 3d after admission was ? nmol/L,significantly higher than that on admission.The blood TET concentration on admission was positively correlated with the epilepsy seizure rate.The blood TET concentration on admission was positively correlated with the CK concentration(P <0.001),and not correlated with the concentrations of CK-MB,LDH,AST,and a-HBDH(all P>0.05).The blood TET concentration on admission was positively correlated with blood TET concentration 3d after admission(P <0.01).Conclusion The concentrations of Tblood ET on admission and 3d after admission can be used as important reference indicators to evaluate yhe severity and prognosis of TET poisoning.更多还原