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靶向药物曲妥珠单抗联合化疗对人类表皮生长因子受体2阳性局部晚期乳腺癌患者临床疗效研究

Clinical effect of trastuzumab combined chemotherapy in patients with HER-2 positive locally advanced breast cancer

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【作者】 袁宏钧

【Author】 YUAN Hong-jun;Department of Mammary Surgery,Zhejiang Provincial People’s Hospital;

【机构】 浙江省人民医院甲乳外科

【摘要】 目的:观察曲妥珠单抗联合化疗对人类表皮生长因子受体2(HER-2)阳性的局部晚期乳腺癌(LABC)临床治疗结果。方法:将228例HER-2阳性手术无法切除的晚期乳腺癌病例随机分到曲妥珠单抗辅助疗法+化疗组或单纯化疗组。其中115例接受曲妥珠单抗+化疗,113例单纯接受化疗,经过10个疗程治疗后,观察两组患者中临床和病理的完全缓解人数及符合手术要求的人数。结果:数据显示与单纯化疗相比,曲妥珠单抗+化疗组病例对治疗的临床完全缓解病例(cCR)(化疗+曲妥珠单抗组89%,单纯化疗组77%)、病理学完全缓解(pCR)病例(两组分别为43%和23%)以及乳房和腋下淋巴结完全缓解(tpCR)病例(分别为39%和20%)比例更高,同时可以使更多的患者获得手术和保留乳房的机会。结论:曲妥珠单抗联合化疗药物治疗HER-2过度表达的局部晚期乳腺癌均有较好的临床疗效,是治疗晚期乳癌并延长生存时间的一种新方法。

【Abstract】 AIM:To observe the efficacy of trastuzumab in treating patients with HER-2positive locally advanced breast cancer(LABC).METHODS:228 HER-2positive patients with unresectable locally advanced breast cancer patients were randomly divided into 2groups.115 patients received trastuzumab plus chemotherapy,113 cases received chemotherapy alone.After 10 courses of treatment,the number of clinical and pathology complete remission and potentially eligible for surgery patients were observed.RESULTS:Compared with chemotherapy group,trastuzumab plus chemotherapy group had more higher proportion in complete remission(cCR)(89%in trastuzumab plus chemotherapy group and 77% in chemotherapy group),pathological complete response(pCR)(43% and23%respectively)and breast and axillary lymph node complete remission(tpCR)(respectively39% and 20%).Trastuzumab plus chemotherapy group had more chance to surgery and breast conservation.CONCLUSION:Trastuzumab combined with chemotherapy is an effective schedule in the treatment of HER-2positive locally advanced breast.

【关键词】 曲妥珠单抗局部晚期乳腺癌化疗
【Key words】 trastuzumabbreast cancerchemotherapy
  • 【文献出处】 中国临床药理学与治疗学 ,Chinese Journal of Clinical Pharmacology and Therapeutics , 编辑部邮箱 ,2015年01期
  • 【分类号】R737.9
  • 【被引频次】9
  • 【下载频次】204
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