【摘要】 目的:探讨速尿联合乌司他丁对行经皮肾镜碎石术(PCNL)患者肾功能的保护作用。方法:选择2012年1月至2013年2月本科住院的44例复杂性肾结石患者,随机分为实验组和对照组,各22例,均行PCNL术,实验组于术前1天、术中、术后1~3d予以速尿20mg静推、乌司他丁2×105 U加入100mL生理盐水静脉滴注,对照组予以等量生理盐水静脉滴注,并检测两组患者术中插管后、术后1、3d患者的肌酐(Cr)和尿素氮(BUN)、肾盂尿β2微球蛋白及尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)。结果:两组患者术后第1、3天尿β2微球蛋白及尿NAG均较术中明显升高(P<0.05),但实验组升高程度明显低于对照组(P<0.05),术后第1天和术后第3天实验组中患者的Cr、BUN水平明显低于对照组(P<0.05)。结论:速尿联合乌司他丁对PCNL术患者肾功能具有一定的保护作用。更多还原

【Abstract】 AIM:To investigate furosemide and ulinastatin’s protective effects on renal function of patients with percutaneous nephrolithotomy.METHODS:44patients diagnosed as complicated renal calculi during January 2012 to February 2013 were selected and they all accepted percutaneous nephrolithotomy,then randomly divided into treatment group and control group,each group had 22 patients.In treatment group,the patients were subjected to the intravenous injection of furosemide(20 mg)and intravenous drip of ulinastatin(2×105 U)plus normal saline(100mL)per day on preoperative day 1,intraoperative and postoperative day 1to 3,and patients in control group only subjected to normal saline(100mL).The levels of Cr,BUN,Urinaryβ2-microglobulin and N-acetyl-β-glucosaminase of pelvic urine were measured post-intubation and first,third day after operation.RESULTS:Urinary β2-microglobulin and N-acetyl-β-glucosaminase of first and third day after operation were significantly higher than those intraoperative in both groups(P<0.05),but the elevated extent in treatment group were smaller than control group(P<0.05);the levels of Cr,BUN of first and third day after operation were higher than those in control group.CONCLUSION:Furosemide and ulinastatin can play a certain role in protecting the renal function of patients with percutaneous nephrolithotomy.更多还原